Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

被引：1626

作者：

du Sert, Nathalie Percie ^{[1
]}

Ahluwalia, Amrita ^{[2
,3
]}

Alam, Sabina ^{[4
]}

Avey, Marc T. ^{[5
]}

Baker, Monya ^{[6
]}

Browne, William J. ^{[7
]}

Clark, Alejandra ^{[8
]}

Cuthill, Innes C. ^{[9
]}

Dirnagl, Ulrich ^{[10
,11
]}

Emerson, Michael ^{[12
]}

Garner, Paul ^{[13
]}

Holgate, Stephen T. ^{[14
]}

Howells, David W. ^{[15
]}

Hurst, Viki ^{[1
]}

Karp, Natasha A. ^{[16
]}

Lazic, Stanley E. ^{[17
]}

Lidster, Katie ^{[1
]}

MacCallum, Catriona J. ^{[18
]}

Macleod, Malcolm ^{[19
]}

Pearl, Esther J. ^{[1
]}

Petersen, Ole H. ^{[20
]}

Rawle, Frances ^{[21
]}

Reynolds, Penny ^{[22
]}

Rooney, Kieron ^{[23
]}

Sena, Emily S. ^{[19
]}

Silberberg, Shai D. ^{[24
]}

Steckler, Thomas ^{[25
]}

Wuerbel, Hanno ^{[26
]}

机构：

[1] NC3Rs, London, England

[2] William Harvey Res Inst, London, England

[3] Queen Mary Univ London, Barts Cardiovasc CTU, London, England

[4] Taylor & Francis Grp, London, England

[5] ICF, Hlth Sci Practice, Durham, NC USA

[6] Nature, San Francisco, CA USA

[7] Univ Bristol, Sch Educ, Bristol, Avon, England

[8] PLOS ONE, Cambridge, England

[9] Univ Bristol, Sch Biol Sci, Bristol, Avon, England

[10] Charite Univ Med Berlin, QUEST Ctr Transforming Biomed Res, Berlin Inst Hlth, Berlin, Germany

[11] Charite Univ Med Berlin, Dept Expt Neurol, Berlin, Germany

[12] Imperial Coll London, Natl Heart & Lung Inst, London, England

[13] Univ Liverpool Liverpool Sch Trop Med, Ctr Evidence Synth Global Hlth, Clin Sci Dept, Liverpool, Merseyside, England

[14] Univ Southampton, Clin & Expt Sci, Southampton, Hants, England

[15] Univ Tasmania, Tasmanian Sch Med, Hobart, Tas, Australia

[16] AstraZeneca, Discovery Sci, R&D, Data Sci & Quantitat Biol, Cambridge, England

[17] Prioris Ai Inc, Ottawa, ON, Canada

[18] Hindawi Ltd, London, England

[19] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[20] Cardiff Univ, Acad Europaea Knowledge Hub, Cardiff, Wales

[21] MRC, London, England

[22] Univ Florida, Coll Med, Dept Anesthesiol, Stat Anesthesiol Res STAR Core, Gainesville, FL USA

[23] Univ Sydney, Fac Med & Hlth, Discipline Exercise & Sport Sci, Sydney, NSW, Australia

[24] NINDS, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[25] Janssen Pharmaceut NV, Beerse, Belgium

[26] Univ Bern, Vetsuisse Fac, Vet Publ Hlth Inst, Bern, Switzerland

来源：

PLOS BIOLOGY | 2020年 / 18卷 / 07期

基金：

英国国家替代、减少和改良动物研究中心;

关键词：

ENVIRONMENTAL ENRICHMENT; LABORATORY-ANIMALS; TREATMENT ALLOCATION; SYSTEMATIC REVIEWS; REGISTERED REPORTS; EXPERIMENTER BIAS; CONTROLLED-TRIALS; RESTRAINT STRESS; TUMOR-GROWTH; DANIO-RERIO;

D O I：

10.1371/journal.pbio.3000411

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting is vital to this process; it allows readers to assess the reliability of the findings and repeat or build upon the work of other researchers. The ARRIVE guidelines (Animal Research: Reporting In Vivo Experiments) were developed in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. Despite widespread endorsement by the scientific community, the impact of ARRIVE on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This explanation and elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2.0, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature. This document also covers advice and best practice in the design and conduct of animal studies to support researchers in improving standards from the start of the experimental design process through to publication.

引用

页数：65

共 257 条

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Multiple determinants of welfare in farmed fish:: stocking density, disturbance, and aggression in Atlantic salmon (Salmo salar) [J].