Leber Congenital Amaurosis - Differential diagnosis, ophthalmological and neuroradiological report of 18 patients

被引:15
作者
Casteels, I
Spileers, W
Demaerel, P
Casaer, P
DeCock, P
Dralands, L
Missotten, L
机构
[1] KATHOLIEKE UNIV LEUVEN HOSP,DEPT RADIOL,B-3000 LOUVAIN,BELGIUM
[2] KATHOLIEKE UNIV LEUVEN HOSP,DEPT OPHTHALMOL,LOUVAIN,BELGIUM
[3] KATHOLIEKE UNIV LEUVEN HOSP,DEPT PEDIAT,LOUVAIN,BELGIUM
关键词
Leber Cogenital Amaurosis; magnetic resonance imaging; brain general development;
D O I
10.1055/s-2007-973785
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Between 1985 and 1995 eighteen babies, presenting to our department with absent visual contact and roving eye movements, showed a non-recordable flash electroretinogram (fERG). This was confirmed when repeated after a one-year interval. In four patients with developmental delay an underlying systemic disorder was diagnosed after a thorough pediatric neurological evaluation: Senior Loken syndrome, neuroaxonal dystrophy, ceroid lipofuscinosis and a yet unclear metabolic disorder were the revised diagnoses. The fourteen remaining patients were diagnosed as having primary idiopathic Leber Congenital Amaurosis (LCA). Three of them showed developmental delay. Ln all three cerebellar abnormalities were visualized on brain computed tomography (CT) and/or magnetic resonance imaging (MRI). Brain CT of the other eleven patients with age appropriate development was normal. We conclude that LCA is a diagnosis of exclusion and a cautious approach with a thorough history and pediatric neurological examination is necessary to exclude a more global pediatric neurological disorder.
引用
收藏
页码:189 / 193
页数:5
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