Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy

被引：76

作者：

Finanger, Erika L. ^{[1
,2
,3
]}

Russman, Barry ^{[1
,2
,3
]}

Forbes, Sean C. ^{[4
]}

Rooney, William D. ^{[5
]}

Walter, Glenn A. ^{[6
]}

Vandenborne, Krista ^{[4
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Pediat, CDRC P, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, CDRC P, Portland, OR 97239 USA

[3] Shriners Hosp Children Portland, Portland, OR 97239 USA

[4] Univ Florida, Dept Phys Therapy, Gainesville, FL 32610 USA

[5] Oregon Hlth & Sci Univ, Adv Imaging Res Ctr, Portland, OR 97239 USA

[6] Univ Florida, Dept Physiol & Funct Genom, Gainesville, FL 32610 USA

来源：

PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA | 2012年 / 23卷 / 01期

关键词：

MRI; Duchenne muscular dystrophy; Skeletal muscle; QUANTIFICATION; TRIAL; BOYS;

D O I：

10.1016/j.pmr.2011.11.004

中图分类号：

R49 [康复医学];

学科分类号：

100232 [康复医学];

摘要：

Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.

引用

页码：1 / +

页数：11

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