Free insulin-like growth factor I:: Are we hunting a ghost?

被引：29

作者：

Bang, P ^{[1
]}

Ahlsén, M ^{[1
]}

Berg, U ^{[1
]}

Carlsson-Skwirut, C ^{[1
]}

机构：

[1] Astrid Lindgren Childrens Hosp, Karolinska Inst, Dept Woman & Child Hlth, Paediat Endocrinol Unit, S-17176 Stockholm, Sweden

来源：

HORMONE RESEARCH | 2001年 / 55卷

关键词：

insulin-like growth factor I; insulin-like growth factor binding proteins; assays; free insulin-like growth factor I; free dissociable insulin-like growth factor I; serum; methodology; bioavailability;

D O I：

10.1159/000063482

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During the last decade, there has been an increasing number of publications reporting concentrations of free dissociable insulin-like growth factor I (IGF-I) in serum or plasma. The goal for attempting to measure free IGF-I in a serum sample in vitro has been to obtain information about the bioactivity of IGF-I in target tissues, and thus relate a measurable parameter to biological responses such as longitudinal growth or glucose disappearance rate. In this review, the serum free IGF-I approach is placed into a physiological perspective. In addition, methodological aspects are discussed and suggestions for the validation of free IGF-I assays are presented. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：84 / 93

页数：10

共 43 条

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[2]

BACH LA, 1993, J BIOL CHEM, V268, P9246

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