Impact of antiepileptic drugs on genesis of psychosis

被引：19

作者：

Noguchi, Takahiro ^{[1
]}

Fukatsu, Naofumi ^{[1
]}

Kato, Hiroko ^{[1
]}

Oshima, Tomohiro ^{[1
]}

Kanemoto, Kousuke ^{[1
]}

机构：

[1] Aichi Med Univ, Dept Neuropsychiat, Nagakute, Aichi 4801195, Japan

来源：

EPILEPSY & BEHAVIOR | 2012年 / 23卷 / 04期

关键词：

Partial epilepsy; Psychosis; Antiepileptic drugs; Zonisamide; Phenytoin; SCHIZOPHRENIA-LIKE PSYCHOSIS; PSYCHIATRIC ADVERSE EVENTS; POSTICTAL PSYCHOSIS; EPILEPSY; ZONISAMIDE; DISORDERS; LEVETIRACETAM; TOPIRAMATE; PREVALENCE; DISEASE;

D O I：

10.1016/j.yebeh.2012.01.012

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

Opinions regarding the impact of antiepileptic drugs (AEDs) on the genesis of psychotic symptoms are varied. To re-examine this issue, the records of adult patients with partial epilepsy and newly added AEDs were retrospectively surveyed. The types of newly added AEDs and clinical characteristics were compared between 38 patients with active psychosis and 212 without psychotic history during a follow-up period of 3 to 6 months after initiation of AED administration. Using multivariate logistic regression analysis, the significance of possible predictive variables for development of psychosis was evaluated, which demonstrated that use of zonisamide (ZNS) and phenytoin (PHT), presence of complex partial seizures (CPS), and low intelligence level were significantly correlated with psychosis. We concluded that ZNS and PHT are possible risk factors for development of psychosis along with clinical variables, including the presence of CPS and low intelligence level. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：462 / 465

页数：4

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