An efficient asymmetric catalytic hydrogenation of 4-aryl coumarins, preparation of a key intermediate in the synthesis of a class of endothelin receptor antagonists

被引：47

作者：

McGuire, MA ^{[1
]}

Shilcrat, SC ^{[1
]}

Sorenson, E ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Dept Synthet Chem, King Of Prussia, PA 19406 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(99)00478-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 4-aryl-3,4-dihydrocoumarin 1 is a critical intermediate in the synthesis of two endothelin receptor antagonists. Asymmetry is introduced by the chiral catalytic hydrogenation of 2. Reduction occurs only if the lactone is open (3). A number of chiral ruthenium and rhodium organometallic species are evaluated as catalysts. The reaction is optimized to produce 1 in high yield and ee. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3293 / 3296

页数：4

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