SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: A molecular epidemiologic case-control study

被引：68

作者：

Cristaudo, A

Foddis, R

Vivaldi, A

Buselli, R

Gattini, V

Guglielmi, G

Cosentino, F

Ottenga, F

Ciancia, E

Libener, R

Filiberti, R

Neri, M

Betta, P

Tognon, M

Mutti, L

Puntoni, R

机构：

[1] Univ Pisa, Dept Endocrinol & Metab Orthoped & Traumatol Occu, Pisa, Italy

[2] Santa Chiara Hosp, Pathol Anat Serv, Pisa, Italy

[3] Azienda Sanitaria Osped, Dept Oncol, Pathol Unit, Alessandria, Italy

[4] Natl Inst Canc Res, Unit Environm Epidemiol, Genoa, Italy

[5] Univ Ferrara, Dept Morphol & Embryol, Sect Histol & Embryol, Ferrara, Italy

[6] S Pietro & Paulo Hosp, Borgosesia, Italy

[7] S Maugeri Fdn Inst Res & Care, Pavia, Italy

来源：

CANCER RESEARCH | 2005年 / 65卷 / 08期

关键词：

D O I：

10.1158/0008-5472.CAN-04-2219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MAls and 6 (33.3%) BUs. The odds ratio for MM Ash- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% Cl, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.

引用

页码：3049 / 3052

页数：4

共 20 条

[1]

Bianchi C, 1997, EUR J CANCER PREV, V6, P162

[2] Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity [J].