Pradimicin therapy of disseminated Candida tropicalis infection in the mouse

被引：4

作者：

Restrepo, MI

Najvar, LK

Fothergill, AW

Graybill, JR

机构：

[1] Univ Texas, Hlth Sci Ctr, San Antonio, TX 78284 USA

[2] S Texas Vet Hlth Care Syst, Audie Murphy Div, San Antonio, TX 78284 USA

来源：

MEDICAL MYCOLOGY | 1998年 / 36卷 / 03期

关键词：

BMS; Candida tropicalis; fluconazole; mouse model; pradimicin;

D O I：

10.1080/02681219880000271

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

EMS 181184 (BMS), an analogue of pradimicin, was administered intravenously to neutropenic mice infected with either a fluconazole-susceptible or a fluconazole-resistant clinical isolate of Candida tropicalis. EMS prolonged survival at doses >3 mg kg(-1) day(-1), and at higher doses reduced tissue counts in mice. EMS was less potent mg for mg than amphotericin B. Combined EMS and amphotericin B were no more effective than either of the individual drugs.

引用

页码：181 / 184

页数：4

共 6 条

[1] IN-VITRO ANTIFUNGAL AND FUNGICIDAL SPECTRA OF A NEW PRADIMICIN DERIVATIVE, BMS-181184 [J].