Nanomaterial mediated optogenetics: opportunities and challenges

被引：132

作者：

Huang, Kai ^{[1
]}

Dou, Qingqing ^{[2
]}

Loh, Xian Jun ^{[2
,3
,4
]}

机构：

[1] Natl Univ Singapore, Dept Biomed Engn, Singapore 117576, Singapore

[2] ASTAR, Inst Mat Res & Engn, 2 Fusionopolis Way,Innovis 08-03, Singapore 0803, Singapore

[3] Natl Univ Singapore, Dept Mat Sci & Engn, Singapore 117574, Singapore

[4] Singapore Eye Res Inst, 20 Coll Rd, Singapore 169856, Singapore

来源：

RSC ADVANCES | 2016年 / 6卷 / 65期

关键词：

UP-CONVERSION NANOPARTICLES; SUPRAMOLECULAR HYDROGEL; CORE/SHELL NANOPARTICLES; OPTICAL MANIPULATION; CATIONIC COPOLYMERS; ACTION-POTENTIALS; NEURAL ACTIVITY; BRAIN ACTIVITY; VIRAL VECTORS; GENE DELIVERY;

D O I：

10.1039/c6ra11289g

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Optogenetics is a promising neuronal modulation strategy in neuroscience, which enables real-time neuromodulation in free-moving animals with high spatiotemporal control. However, it still suffers from several disadvantages, including low penetration of excitation light and the invasiveness of the insertion of the light delivery system. The incorporation of nanomaterials with different properties into optogenetics may bring new opportunities to solve the problems encountered in optogenetics, from the delivery/expression of the optogene to the stimulation/inhibition and follow-up sensing of neural activity. The challenges of nanomaterial-mediated optogenetics are also discussed. This review elaborates on the feasibility of incorporating nanomaterials into optogenetics and analyzes the benefits of nanomaterial-mediated optogenetics.

引用

页码：60896 / 60906

页数：11

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