Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules

被引：112

作者：

Hoelzl, Christine ^{[1
]}

Knasmueller, Siegfried ^{[1
]}

Wagner, Karl-Heinz ^{[2
]}

Elbling, Leonilla ^{[1
]}

Huber, Wolfgang ^{[1
]}

Kager, Nina ^{[1
]}

Ferk, Franziska ^{[1
]}

Ehrlich, Veronika ^{[1
]}

Nersesyan, Armen ^{[1
]}

Neubauer, Oliver ^{[2
]}

Desmarchelier, Aurelien ^{[3
]}

Marin-Kuan, Maricel ^{[3
]}

Delatour, Thierry ^{[3
]}

Verguet, Clotilde ^{[3
]}

Bezencon, Claudine ^{[3
]}

Besson, Amelie ^{[3
]}

Grathwohl, Dominik ^{[3
]}

Simic, Tatjana ^{[4
]}

Kundi, Michael ^{[5
]}

Schilter, Benoit ^{[3
]}

Cavin, Christophe ^{[3
]}

机构：

[1] Med Univ Vienna, Inst Canc Res, Dept Med 1, A-1090 Vienna, Austria

[2] Univ Vienna, Dept Nutrit Sci, Vienna, Austria

[3] Nestle Res Ctr, CH-1000 Lausanne, Switzerland

[4] Univ Belgrade, Fac Med, Inst Med & Clin Biochem, Belgrade, Serbia

[5] Med Univ Vienna, Inst Environm Hlth, Vienna, Austria

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2010年 / 54卷 / 12期

关键词：

Antioxidants; Chlorogenic acids; Instant coffee; Intervention trial; INDUCED DNA-DAMAGE; GLUTATHIONE S-TRANSFERASES; COMET ASSAY; IN-VITRO; ANTIOXIDANT CAPACITY; LIPID-PEROXIDATION; PLASMA; CONSUMPTION; DISEASE; HEALTH;

D O I：

10.1002/mnfr.201000048

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Scope: Coffee is among the most frequently consumed beverages. Its consumption is inversely associated to the incidence of diseases related to reactive oxygen species; the phenomenon may be due to its antioxidant properties. Our primary objective was to investigate the impact of consumption of a coffee containing high levels of chlorogenic acids on the oxidation of proteins, DNA and membrane lipids; additionally, other redox biomarkers were monitored in an intervention trial. Methods and results: The treatment group (n = 36) consumed instant coffee co-extracted from green and roasted beans, whereas the control consumed water (800 mL/P/day, 5 days). A global statistical analysis of four main biomarkers selected as primary outcomes showed that the overall changes are significant. 8-Isoprostaglandin F2 alpha in urine declined by 15.3%, 3-nitrotyrosine was decreased by 16.1%, DNA migration due to oxidized purines and pyrimidines was (not significantly) reduced in lymphocytes by 12.5 and 14.1%. Other markers such as the total antioxidant capacity were moderately increased; e.g. LDL and malondialdehyde were shifted towards a non-significant reduction. Conclusion: The oxidation of DNA, lipids and proteins associated with the incidence of various diseases and the protection against their oxidative damage may be indicative for beneficial health effects of coffee.

引用

页码：1722 / 1733

页数：12

共 64 条

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