Marginal zone B cells

被引：375

作者：

Pillai, S ^{[2
]}

Cariappa, A

Moran, ST

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02129 USA

[2] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02129 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2005年 / 23卷

关键词：

follicular B cells; transitional B cells; B cell receptor; Notch2;

D O I：

10.1146/annurev.immunol.23.021704.115728

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our views regarding the origins and functions of splenic marginal zone B cells have changed considerably over the past few years. Perspectives regarding the development and function of these cells vary considerably between investigators studying human and rodent immunology. Marginal zone B cells are now recognized to constitute a distinct naive B lymphoid lineage. Considerable progress has been made regarding the mechanisms involved in marginal zone B cell development in the mouse. Many of the molecular events that participate in the retention of this lineage of B cells in the marginal zone have been identified. Here, we discuss the functions of these cells in both innate and adaptive immunity. We also attempt to reconcile differing viewpoints regarding the generation and function of marginal zone B cells in rodents and primates.

引用

页码：161 / 196

页数：36

共 161 条

[1] Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population [J].