Synthetic utility of bifunctional thiophene derivatives and antimicrobial evaluation of the newly synthesized agents

被引：39

作者：

Abu-Hashem, Ameen A. ^{[2
]}

Abu-Zied, Khadiga M. ^{[2
]}

El-Shehry, Mohamed F. ^{[1
]}

机构：

[1] Natl Res Ctr, Green Chem Dept, Giza 12622, Egypt

[2] Natl Res Ctr, Photochem Dept, Giza 12622, Egypt

来源：

MONATSHEFTE FUR CHEMIE | 2011年 / 142卷 / 05期

关键词：

Ethyl thiophene-3-carboxylate; Thienopyrimidines; Thienopyridines; Tetrazole derivatives; Pyrazole derivatives; Antimicrobial activity; FUSED PYRIMIDINES; PYRIDAZINES;

D O I：

10.1007/s00706-011-0456-z

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The key intermediate ethyl 2-amino-5-benzoyl-4-methylthiophene-3-carboxylate was prepared by a Gewald reaction starting from benzoylacetone, sulfur, and ethyl cyanoacetate in the presence of diethylamine. This intermediate reacted with various reagents to afford different fused and polyfunctional substituted thiophenes. Antimicrobial screening of the synthesized compounds exhibited promising antimicrobial activities.

引用

页码：539 / 545

页数：7

共 28 条

[1]

[Anonymous], 1985, PHARM IND

[2]

Amide derivatives of [6-(5-methyl-3-phenylpyrazole-1-yl)-3(2H)pyridazinone-2-yl]acetic acids as potential a analgesic and anti-inflammatory compounds [J].

Banoglu, E ;

Akoglu, Ç ;

Ünlü, S ;

Küpeli, E ;

Yesilada, E ;

Sahin, EF .

ARCHIV DER PHARMAZIE, 2004, 337 (01) :7-14

[3]

Bekhit AA, 1998, PHARMAZIE, V53, P539

[4]

Bhuiyan M. M. H., 2005, J APPL SCI RES, V1, P218

[5]

Bhuiyan Md. Mosharef Hossain, 2006, Acta Pharmaceutica (Zagreb), V56, P441

[6]

Bhuiyan MMH, 2005, CROAT CHEM ACTA, V78, P633

[7]

Pyridazines.: Part 36:: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones [J].

Coelho, A ;

Sotelo, E ;

Fraiz, N ;

Yáñez, M ;

Laguna, R ;

Cano, E ;

Raviña, E .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (02) :321-324

[8]

COLLEE G, 1996, PRACTICAL MED MICROB

[9]

Dogruer DS, 2003, TURK J CHEM, V27, P727

[10]

THE SYNTHESIS OF SOME 3-AMINO-2-HALOMETHYLQUINAZOLIN-4(3H)-ONES, 2-HALOMETHYL-3-(SUBSTITUTED-AMINO)QUINAZOLIN-4(3H)-ONES AND 2-HALOMETHYL-3-HETARYLQUINAZOLIN-4(3H)-ONES AS POTENTIAL PLANT PROTECTING AGENTS [J].

FETTER, J ;

CZUPPON, T ;

HORNYAK, G ;

FELLER, A .

TETRAHEDRON, 1991, 47 (45) :9393-9410

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