CAR-T cells and allogeneic hematopoietic stem cell transplantation for relapsed/refractory B-cell acute lymphoblastic leukemia

被引：41

作者：

Liu, Jun ^{[1
]}

Zhang, Xi ^{[1
]}

Zhong, Jiang F. ^{[2
,3
]}

Zhang, Cheng ^{[1
]}

机构：

[1] Third Mil Med Univ, Xinqiao Hosp, Dept Hematol, Chongqing 400037, Peoples R China

[2] Univ Southern Calif, Div Periodontol Diagnost Sci & Dent Hyg, Los Angeles, CA USA

[3] Univ Southern Calif, Herman Ostrow Sch Dent, Div Biomed Sci, Los Angeles, CA USA

来源：

IMMUNOTHERAPY | 2017年 / 9卷 / 13期

关键词：

allogeneic hematopoietic stem cell transplantation; B-cell acute lymphoblastic leukemia; CAR-T cells; relapsed/refractory; CHIMERIC ANTIGEN RECEPTOR; THERAPY; MALIGNANCIES; LYMPHOMA; CD28; CD19; IDENTIFICATION; IMMUNOTHERAPY; PERSISTENCE; REMISSIONS;

D O I：

10.2217/imt-2017-0072

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Relapsed/refractory acute lymphoblastic leukemia (ALL) has a low remission rate after chemotherapy, a high relapse rate and poor long-term survival even when allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed. Chimeric antigen receptors redirected T cells (CAR-T cells) can enhance disease remission with a favorable outcome for relapsed/refractory ALL, though some cases quickly relapsed after CAR-T cell treatment. Thus, treatment with CAR-T cells followed by allo-HSCT may be the best way to treat relapsed/refractory ALL. In this review, we first discuss the different types of CAR-T cells. We then discuss the treatment of relapsed/refractory ALL using only CAR-T cells. Finally, we discuss the use of CAR-T cells, followed by allo-HSCT, for the treatment of relapsed/refractory ALL.

引用

页码：1115 / 1125

页数：11

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