Intracellular control of gene trafficking using liposomes as drug carriers

被引：55

作者：

Harashima, H

Shinohara, Y

Kiwada, H

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2001年 / 13卷 / 01期

关键词：

liposomes; drug delivery system; gene delivery; carrier system; nuclear localization signal;

D O I：

10.1016/S0928-0987(00)00211-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The objective of this review is to summarize some of the critical barriers in gene delivery and recent progress in overcoming such barriers using non-viral carrier systems. Receptor-mediated endocytosis is generally considered to be a principal entering pathway. Therefore, endosomal escape is an essential step for achieving efficient transfection. The nuclear membrane is also a critical barrier in gene delivery and the application of the nuclear localization signal is discussed, based on recent strategies. It is essential to optimize the carrier system, in order to enhance the transfection ability equivalent to a viral system. The importance of developing an intracellular pharmacokinetic model of genes is emphasized in the optimization of non-viral carrier systems. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：85 / 89

页数：5

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