Nucleus accumbens long-term depression and the expression of behavioral sensitization

被引：225

作者：

Brebner, K

Wong, TP

Liu, LD

Liu, YT

Campsall, P

Gray, S

Phelps, L

Phillips, AG ^{[1
]}

Wang, YT

机构：

[1] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada

[2] Univ British Columbia, Dept Med, Vancouver, BC V6T 2B5, Canada

[3] Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 2B5, Canada

来源：

SCIENCE | 2005年 / 310卷 / 5752期

关键词：

D O I：

10.1126/science.1116894

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Drug-dependent neural plasticity related to drug addiction and schizophrenia can be modeled in animals as behavioral sensitization, which is induced by repeated noncontingent or self-administration of many drugs of abuse. Molecular mechanisms that are critical for behavioral sensitization have yet to be specified. Long-term depression (LTD) of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor (AMPAR)-mediated synaptic transmission in the brain has been proposed as a cellular substrate for learning and memory. The expression of LTD in the nucleus accumbens (NAc) required clathrin-dependent endocytosis of postsynaptic AMPARs. NAc LTD was blocked by a dynamin-derived peptide that inhibited clathrin-mediated endocytosis or by a GluR2-derived peptide that blocked regulated AMPAR endocytosis. Systemic or intra-NAc infusion of the membrane-permeable GluR2 peptide prevented the expression of amphetamine-induced behavioral sensitization in the rat.

引用

页码：1340 / 1343

页数：4

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