Phospholamban and cardiac contractility

被引：98

作者：

Frank, K ^{[1
]}

Kranias, EG ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, Cincinnati, OH 45267 USA

来源：

ANNALS OF MEDICINE | 2000年 / 32卷 / 08期

关键词：

cardiac contractility; phospholamban; relaxation; sarcoplasmic reticulum;

D O I：

10.3109/07853890008998837

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Over the last three decades, our knowledge and understanding of the role of phospholamban and its modulation of sarcoplasmic reticulum (SR) function has advanced significantly. Phospholamban is a key regulator of cardiac contractility and modulates SR Ca2+ sequestration by inhibiting the SR Ca2+ -ATPase (SERCA) in its dephosphorylated state. Upon phosphorylation, which is mediated through beta -adrenergic stimulation, the inhibitory effect of phospholamban on the function of SERCA is relieved. This review summarizes recent advances that have been made towards understanding the modulation of SR Ca2+-sequestration by phospholamban through the generation and characterization of genetically altered animal models. It also discusses the role of phospholamban in human heart failure and recent attempts to restore SR function in experimentally induced and human heart failure, which may be translated into future therapeutic approaches in the treatment of this disease.

引用

页码：572 / 578

页数：7

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