Asymmetric direct α,β-functionalization of allenes via asymmetric carbopalladation

被引：29

作者：

Hiroi, K ^{[1
]}

Kato, F ^{[1
]}

Yamagata, A ^{[1
]}

机构：

[1] Tohoku Coll Pharm, Dept Synthet Organ Chem, Sendai, Miyagi 9818558, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 05期

关键词：

D O I：

10.1246/cl.1998.397

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric direct a,p-functionalization of allenes with chiral phosphine ligands was successfully achieved with extremely high enantioselectivity via asymmetric carbopalladation to the racemic allenes. The same palladium-catalyzed alkylation of a chiral allene was executed with complete enantiospecificity. The stereochemistry of this reaction was determined and the mechanism of this asymmetric induction is proposed.

引用

页码：397 / 398

页数：2

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