Immobilization and bone structure in humans

被引:69
作者
Sievanen, Harri [1 ]
机构
[1] UKK Inst Hlth Promot Res, Bone Res Grp, FI-33501 Tampere, Finland
关键词
Spinal cord injury; Bed rest; Spaceflight; Disuse; Bone strength; Osteoporosis; SPINAL-CORD-INJURY; QUANTITATIVE COMPUTED-TOMOGRAPHY; LONG-DURATION SPACEFLIGHT; DAYS BED REST; MINERAL DENSITY; SHAFT FRACTURE; PERMANENT OSTEOPOROSIS; MECHANICAL-PROPERTIES; TERM IMMOBILIZATION; LOWER-EXTREMITIES;
D O I
10.1016/j.abb.2010.07.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Long-term immobilization is known to result in substantial bone loss. The present review examined the existing evidence for deterioration of bone structure during long-term disuse in humans. Paralysis due to spinal cord injury, long-term exposure to microgravity in space or tightly restricted mobility during bed rest provide reasonable models to assess the influence of immobilization on bone structure. Expectedly, the duration of immobilisation was the major determinant of bone loss, but irrespective of whether the skeletal unloading was due to irrecoverable paralysis, long-term spaceflight or bed rest, the mean pattern of structural deterioration of bone, mainly manifest as substantial cortical thinning and trabecular bone loss, was quite similar. However, skeletal responses to disuse can be highly variable between individuals. Apparently the relative decline in individual's bone loading in relation to loading prior to immobilization accounts for inter-individual variation. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:146 / 152
页数:7
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