Mucosal immune response to Tropheryma whipplei

被引：5

作者：

Ring, S

Schneider, T

Marth, T ^{[1
]}

机构：

[1] Deutsch Klin Diagnost, Div Gastroenterol, D-65191 Wiesbaden, Germany

[2] Deutsch Klin Diagnost, European Study Ctr Whipples Dis, D-65191 Wiesbaden, Germany

[3] Free Univ Berlin, Klinikum Benjamin Franklin, Div Gastroenterol & Infect Dis, Dept Internal Med, D-12200 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2003年 / 293卷 / 01期

关键词：

Whipple's disease; Tropberyma whipplei; predisposed immunodefects; IL-12; IFN-gamma;

D O I：

10.1078/1438-4221-00245

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Whipple's disease is a rare infectious disease caused by the ubiquitously occurring Tropheryma whipplei in predisposed persons. Genetic or acquired defects in the mucosal and peripheral immune system become apparent as diminished Th1 immune functions with decreased production of IL-12 and IFN-gamma accompanied by an increased secretion of IL-4. These defects may enable T whipplei to survive and replicate. The recently established cultivation of the bacterium in HEL cells and the isolation from infected intestinal biopsies enable a multitude of experimental possibilities which may lead to an improved diagnosis as well as understanding of the etiology and pathogenesis of Whipple's disease.

引用

页码：69 / 76

页数：8

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