Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone

被引：124

作者：

Boveris, A

Cadenas, E

机构：

[1] Univ So Calif, Sch Pharm, Dept Mol Pharmacol & Toxicol, Los Angeles, CA 90089 USA

[2] Univ Buenos Aires, Sch Pharm & Biochem, Dept Phys Chem, Buenos Aires, DF, Argentina

来源：

IUBMB LIFE | 2000年 / 50卷 / 4-5期

关键词：

apoptosis; hydrogen peroxide; mitochondria; nitric oxide; ubiquinone;

D O I：

10.1080/15216540051080912

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are considered the major cellular site for hydrogen peroxide production, a process that is kinetically controlled by the availability of oxygen and nitric oxide to cytochrome oxidase and of ADP to F-1-ATPase, The multisite regulation of mitochondrial respiration and energy-transducing pathways support a critical regulatory role of mitochondrion in cell signaling pathways. The cellular steady-state levels of hydrogen peroxide and the role of mitochondria in maintaining these levels are reviewed.

引用

页码：245 / 250

页数：6

共 63 条

[1] [Anonymous], 1997, OXYGEN GENE EXPRESSI
[2] Estimation of H2O2 gradients across biomembranes
Antunes, F
Cadenas, E
[J]. FEBS LETTERS, 2000, 475 (02) : 121 - 126
[3] Bridge over troubled waters:: Sensing stress by disulfide bond formation
Åslund, F
Beckwith, J
[J]. CELL, 1999, 96 (06) : 751 - 753
[4] Nitric oxide donors, nitrosothiols and mitochondrial respiration inhibitors induce caspase activation by different mechanisms
Borutaite, V
Morkuniene, R
Brown, GC
[J]. FEBS LETTERS, 2000, 467 (2-3) : 155 - 159
[5] MITOCHONDRIAL PRODUCTION OF SUPEROXIDE ANIONS AND ITS RELATIONSHIP TO ANTIMYCIN INSENSITIVE RESPIRATION
BOVERIS, A
CADENAS, E
[J]. FEBS LETTERS, 1975, 54 (03): : 311 - 314
[6] ROLE OF UBIQUINONE IN MITOCHONDRIAL GENERATION OF HYDROGEN-PEROXIDE
BOVERIS, A
CADENAS, E
STOPPANI, AOM
[J]. BIOCHEMICAL JOURNAL, 1976, 156 (02) : 435 - 444
[7] Boveris A, 2000, ANN NY ACAD SCI, V899, P121
[8] CELLULAR PRODUCTION OF HYDROGEN-PEROXIDE
BOVERIS, A
CHANCE, B
OSHINO, N
[J]. BIOCHEMICAL JOURNAL, 1972, 128 (03) : 617 - &
[9] Bifurcated ubihydroquinone oxidation in the cytochrome bc(1) complex by proton-gated charge transfer
Brandt, U
[J]. FEBS LETTERS, 1996, 387 (01) : 1 - 6
[10] Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release
Brookes, PS
Salinas, EP
Darley-Usmar, K
Eiserich, JP
Freeman, BA
Darley-Usmar, VM
Anderson, PG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) : 20474 - 20479

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