Recent advances in peptide chiral selectors for electrophoresis and liquid chromatography

被引：28

作者：

Bluhm, L

Huang, JM

Li, TY

机构：

[1] Mississippi State Univ, Dept Chem, Mississippi State, MS 39762 USA

[2] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2005年 / 382卷 / 03期

关键词：

peptide chiral selector; chiral separation; combinatorial library; chiral stationary phase; electrophoresis; chiral chromatography;

D O I：

10.1007/s00216-005-3171-y

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The application of peptides in chiral separations using techniques such as capillary electrophoresis (CE), electrokinetic capillary chromatography (EKC) and liquid chromatography is the focus of this review. Methods for finding peptide selectors using combinatorial library approaches are discussed, as well as recent advances in the use of peptides as general chiral selectors for electrophoresis and liquid chromatography. One example shows the effectiveness of polymeric dipeptide surfactants as general chiral selectors for electrophoresis. Another example shows the versatility of oligoproline chiral stationary phases, exhibiting resolution for a number of racemic analytes comparable to other well-established chiral stationary phases.

引用

收藏

页码：592 / 598

页数：7

相关论文

共 45 条

[1] PROTEINS AND PEPTIDES AS CHIRAL SELECTORS IN LIQUID-CHROMATOGRAPHY [J].

ALLENMARK, SG ;

ANDERSSON, S .

JOURNAL OF CHROMATOGRAPHY A, 1994, 666 (1-2) :167-179

[2]

ALLENMARK SG, 1991, ACS SYM SER, V471, P114

[3] Role of the carbohydrate moieties in chiral recognition on teicoplanin-based LC stationary phases [J].

Berthod, A ;

Chen, XH ;

Kullman, JP ;

Armstrong, DW ;

Gasparrini, F ;

D'Acquarica, I ;

Villani, C ;

Carotti, A .

ANALYTICAL CHEMISTRY, 2000, 72 (08) :1767-1780

[4] Examination of structural changes of polymeric amino acid-based surfactants on enantioselectivity: Effect of amino acid order, steric factors, and number and position of chiral centers [J].

Billiot, E ;

Warner, IM .

ANALYTICAL CHEMISTRY, 2000, 72 (08) :1740-1748

[5] Chiral separations using dipeptide polymerized surfactants: Effect of amino acid order [J].

Billiot, E ;

Macossay, J ;

Thibodeaux, S ;

Shamsi, SA ;

Warner, IM .

ANALYTICAL CHEMISTRY, 1998, 70 (07) :1375-1381

[6]

BIRKINSHAW F L, 1992, Analytical Proceedings, V29, P235, DOI 10.1039/ap9922900235

[7] Resolution of tert-butyl-1-(2-methylnaphthyl)phosphine oxide using selectors identified from a chemical combinatorial library [J].

Blodgett, J ;

Wang, Y ;

Li, TY ;

Polavarapu, PL ;

Drabowicz, J ;

Pietrusiewicz, KM ;

Zygo, K .

ANALYTICAL CHEMISTRY, 2002, 74 (20) :5212-5216

[8] Chiral recognition:: Design and preparation of chiral stationary phases using selectors derived from Ugi multicomponent condensation reactions and a combinatorial approach [J].

Brahmachary, E ;

Ling, FH ;

Svec, F ;

Fréchet, JMJ .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2003, 5 (04) :441-450

[9] New CSPs based on peptidomimetics:: efficient chiral selectors in enantioselective separations [J].

Burguete, MI ;

Fréchet, JMJ ;

García-Verdugo, E ;

Janco, M ;

Luis, SV ;

Svec, F ;

Vicent, MJ ;

Xu, MC .

POLYMER BULLETIN, 2002, 48 (01) :9-15

[10] Combinatorial synthesis of highly selective cyclohexapeptides for separation of amino acid enantiomers by capillary electrophoresis [J].

Chiari, M ;

Desperati, V ;

Manera, E ;

Longhi, R .

ANALYTICAL CHEMISTRY, 1998, 70 (23) :4967-4973

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