Synthesis and biological evaluation of 3-amino-propan-1-ol based poly(ether imine) dendrimers

被引：28

作者：

Krishna, TR

Jain, S

Tatu, US ^{[1
]}

Jayaraman, N

机构：

[1] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

TETRAHEDRON | 2005年 / 61卷 / 17期

关键词：

cytotoxicity; dendrimers; Michael addition; Raney cobalt;

D O I：

10.1016/j.tet.2005.02.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general synthetic strategy for the rapid construction of poly(ether imine) dendrons and dendrimers with a nitrogen core, originating from 3-ainino-propan-1-ol, is described. A new trifunctional monomer, namely, 3-[bis-(3-hydroxypropyl)aminolpropan-1-ol, was used in a divergent synthesis of dendrimers up to the third generation. This method permitted installation of, either alcohol, amine, nitrile, ester or carboxylic acid groups at the peripheries the dendrimers. Cytotoxicity studies on water-soluble carboxylic acid terminated dendrimers were conducted and these studies revealed that poly(ether imine) dendrimers were non-toxic. These results illustrate that poly(ether imine) dendrimers are useful for biological studies. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：4281 / 4288

页数：8

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