Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa

被引：299

作者：

Tateda, K

Comte, R

Pechere, JC

Köhler, T

Yamaguchi, K

Van Delden, C

机构：

[1] Univ Geneva, Sch Med, Dept Genet & Microbiol, CH-1211 Geneva 14, Switzerland

[2] Toho Univ, Sch Med, Dept Microbiol, Tokyo 153, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期

关键词：

D O I：

10.1128/AAC.45.6.1930-1933.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report that 2 mug of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.

引用

页码：1930 / 1933

页数：4

共 29 条

[1] XCP-MEDIATED PROTEIN SECRETION IN PSEUDOMONAS-AERUGINOSA - IDENTIFICATION OF 2 ADDITIONAL GENES AND EVIDENCE FOR REGULATION OF XCP GENE-EXPRESSION
AKRIM, M
BALLY, M
BALL, G
TOMMASSEN, J
TEERINK, H
FILLOUX, A
LAZDUNSKI, A
[J]. MOLECULAR MICROBIOLOGY, 1993, 10 (02) : 431 - 443
[2] PROTEIN SECRETION IN PSEUDOMONAS-AERUGINOSA - CHARACTERIZATION OF 7 XCP GENES AND PROCESSING OF SECRETORY APPARATUS COMPONENTS BY PREPILIN PEPTIDASE
BALLY, M
FILLOUX, A
AKRIM, M
BALL, G
LAZDUNSKI, A
TOMMASSEN, J
[J]. MOLECULAR MICROBIOLOGY, 1992, 6 (09) : 1121 - 1131
[3] Regulation of the xcp secretion pathway by multiple quorum-sensing modulons in Pseudomonas aeruginosa
ChaponHerve, V
Akrim, M
Latifi, A
Williams, P
Lazdunski, A
Bally, M
[J]. MOLECULAR MICROBIOLOGY, 1997, 24 (06) : 1169 - 1178
[4] DIVERSE PSEUDOMONAS-AERUGINOSA GENE-PRODUCTS STIMULATE RESPIRATORY EPITHELIAL-CELLS TO PRODUCE INTERLEUKIN-8
DIMANGO, E
ZAR, HJ
BRYAN, R
PRINCE, A
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) : 2204 - 2210
[5] LONG-TERM EFFECT OF ERYTHROMYCIN THERAPY IN PATIENTS WITH CHRONIC PSEUDOMONAS-AERUGINOSA INFECTION
FUJII, T
KADOTA, J
KAWAKAMI, K
IIDA, K
SHIRAI, R
KASEDA, M
KAWAMOTO, S
KOHNO, S
[J]. THORAX, 1995, 50 (12) : 1246 - 1252
[6] Production of N-acyl-L-homoserine lactones by P-aeruginosa isolates from chronic lung infections associated with cystic fibrosis
Geisenberger, O
Givskov, M
Riedel, K
Hoiby, N
Tümmler, B
Eberl, L
[J]. FEMS MICROBIOLOGY LETTERS, 2000, 184 (02) : 273 - 278
[7] DIFFUSE PANBRONCHIOLITIS AND CYSTIC-FIBROSIS - EAST MEETS WEST
HOIBY, N
[J]. THORAX, 1994, 49 (06) : 531 - 532
[8] CHROMOSOMAL GENETICS OF PSEUDOMONAS
HOLLOWAY, BW
KRISHNAPILLAI, V
MORGAN, AF
[J]. MICROBIOLOGICAL REVIEWS, 1979, 43 (01) : 73 - 102
[9] Macrolides for the treatment of Pseudomonas aeruginosa infections?
Howe, RA
Spencer, RC
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (02) : 153 - 155
[10] Long-term azithromycin may improve lung function in children with cystic fibrosis
Jaffé, A
Francis, J
Rosenthal, M
Bush, A
[J]. LANCET, 1998, 351 (9100) : 420 - 420

← 1 2 3 →