Assay by nuclear magnetic resonance spectroscopy: quantification limits

被引：73

作者：

Griffiths, L ^{[1
]}

Irving, AM ^{[1
]}

机构：

[1] Zeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

来源：

ANALYST | 1998年 / 123卷 / 05期

关键词：

NMR spectroscopy; signal-to-noise ratio; quantification;

D O I：

10.1039/a800625c

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of an internal standard in NMR spectroscopy to determine the strength (assay) of a material incurs several errors. The sources and magnitude of these errors were examined so that they may be minimised. Minimisation of these errors will result in strength determinations of these materials with 95% confidence limits of +/-1%.

引用

页码：1061 / 1068

页数：8

共 13 条

[1]

ATTALIA A, 1984, ANAL CHEM S SER ANAL, V19, P363

[2]

COOKSON DJ, 1982, ANAL CHEM, V54, P2593

[3]

DEROME AE, 1987, MODERN NMR TECHNIQUE, P71

[4] APPLICATION OF FOURIER TRANSFORM SPECTROSCOPY TO MAGNETIC RESONANCE [J].

ERNST, RR ;

ANDERSON, WA .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1966, 37 (01) :93-+

[5]

GRIFFITHS G, 1984, Analytical Proceedings, V21, P502

[6]

ISMAIL IM, 1986, METHODOL SURV BIOCH, V16, P337

[7]

LINDGREN B, 1993, PHARMEUROPA, V5, P51

[8] DIGITIZATION AND DATA-PROCESSING IN FOURIER-TRANSFORM NMR [J].

LINDON, JC ;

FERRIGE, AG .

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1980, 14 :27-66

[9] H-1-NMR ANALYSIS OF MIXTURES USING INTERNAL STANDARDS - A QUANTITATIVE EXPERIMENT FOR THE INSTRUMENTAL ANALYSIS LABORATORY [J].

PETERSON, J .

JOURNAL OF CHEMICAL EDUCATION, 1992, 69 (10) :843-845

[10] A QUALITATIVE-QUANTITATIVE H-1-NMR EXPERIMENT FOR THE INSTRUMENTAL ANALYSIS LABORATORY [J].

PHILLIPS, JS ;

LEARY, JJ .

JOURNAL OF CHEMICAL EDUCATION, 1986, 63 (06) :545-546

← 1 2 →