Fast gas chromatography mass spectrometry analysis of drugs in urine with hyperthermal surface ionization in supersonic molecular beams

被引:11
作者
Dagan, S
Amirav, A [1 ]
机构
[1] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel
[2] Israel Inst Biol Res, IL-74100 Ness Ziona, Israel
来源
EUROPEAN MASS SPECTROMETRY | 1998年 / 4卷 / 01期
关键词
drugs; GC/MS; hyperthermal surface ionization;
D O I
10.1255/ejms.186
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
A new approach for drug screening and detection in urine has been developed and studied. Fast gas chromatography/mass spectrometry (GC/MS) in combination with supersonic molecular beams was applied, employing hyperthermal surface ionization (HSI). Fast GC/MS (less than three minutes) screening of drugs in an untreated urine sample, at a detection limit of less than 100 ppb is shown. For this purpose, a new technique of "in-needle vaporization injection" (INVI) was developed for the introduction of untreated urine into the GC injector, leading to a minimal amount of salt and residue deposit on the GC liner and column. This new technique is compared with conventional syringe injection. Hyperthermal surface ionization of drugs is discussed in terms of ionization efficiency, selectivity and mass spectral appearance.
引用
收藏
页码:15 / 21
页数:7
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