Synthesis and characterization of biocompatible thermo-responsive gelators based on ABA triblock copolymers

被引：142

作者：

Li, CM

Tang, YQ

Armes, SP

Morris, CJ

Rose, SF

Lloyd, AW

Lewis, AL

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Univ Brighton, Sch Pharm & Biomol Sci, Brighton BN2 4GJ, E Sussex, England

[3] Biocompat UK Ltd, Farnham GU9 8QL, Surrey, England

来源：

BIOMACROMOLECULES | 2005年 / 6卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/bm049331k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of biocompatible, thermo-responsive ABA triblock copolymers in which the outer A blocks comprise poly (N-isopropylacrylamide) and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine) is achieved using atom transfer radical polymerization with a commercially available bifunctional initiator. These novel triblock copolymers are water-soluble in dilute aqueous solution at 20 degrees C and pH 7.4 but form free-standing physical gels at 37 degrees C due to hydrophobic interactions between the poly(N-isopropylacrylamide) blocks. This gelation is reversible, and the gels are believed to contain nanosized micellar domains; this suggests possible applications in drug, delivery and tissue engineering.

引用

页码：994 / 999

页数：6

共 25 条

[1] Associative graft copolymers comprising a poly(N-isopropylacrylamide) backbone and end-functionalized polyoxyethylene side chains.: Synthesis and aqueous solution properties [J].