Diffusion in polyelectrolyte hydrogels: Application of an obstruction-scaling model to solute diffusion in calcium alginate

被引：30

作者：

Amsden, B ^{[1
]}

机构：

[1] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

来源：

MACROMOLECULES | 2001年 / 34卷 / 05期

关键词：

D O I：

10.1021/ma001450e

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

An obstruction-scaling model of the diffusion of solute molecules within polyelectrolyte gels is presented. Two release medium conditions are considered: low ionic strength and high ionic strength. The model is tested against experimental data of protein diffusion in calcium alginate hydrogels. The model provides very good agreement to the experimental results, successfully predicting the effects of polymer concentration, release medium ionic strength, and polymer chain flexibility.

引用

页码：1430 / 1435

页数：6

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