Synthesis and kinetics of hydrolysis of 3,5-dimethyl-N-acetyl-p-benzoquinone imine - An undergraduate laboratory

被引：3

作者：

Buccigross, JM ^{[1
]}

Metz, C ^{[1
]}

Elliot, L ^{[1
]}

Becker, P ^{[1
]}

Earley, AS ^{[1
]}

Hayes, JW ^{[1
]}

Novak, M ^{[1
]}

Underwood, GA ^{[1
]}

机构：

[1] MIAMI UNIV, OXFORD, OH 45056 USA

来源：

JOURNAL OF CHEMICAL EDUCATION | 1996年 / 73卷 / 04期

关键词：

D O I：

10.1021/ed073p364

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：364 / 367

页数：4

共 8 条

[1]

CORCORAN GB, 1980, MOL PHARMACOL, V18, P536

[2] N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].

DAHLIN, DC ;

MIWA, GT ;

LU, AYH ;

NELSON, SD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331

[3] STUDIES ON THE MECHANISM OF TOXICITY OF ACETAMINOPHEN - SYNTHESIS AND REACTIONS OF N-ACETYL-2,6-DIMETHYL-PARA-BENZOQUINONE AND N-ACETYL-3,5-DIMETHYL-PARA-BENZOQUINONE IMINES [J].

FERNANDO, CR ;

CALDER, IC ;

HAM, KN .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) :1153-1158

[4] A practical procedure for determining rate constants in consecutive first-order systems [J].

Kahley, MJ ;

Novak, M .

JOURNAL OF CHEMICAL EDUCATION, 1996, 73 (04) :359-364

[5]

MULDER GJ, 1987, BIOCHEM PHARMACOL, V27, P1641

[6] HYDROLYSIS OF N-ACETYL-PARA-BENZOQUINONE IMINES - PH-DEPENDENCE OF THE PARTITIONING OF A TETRAHEDRAL INTERMEDIATE [J].

NOVAK, M ;

BONHAM, GA ;

MULERO, JJ ;

PELECANOU, M ;

ZEMIS, JN ;

BUCCIGROSS, JM ;

WILSON, TC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (12) :4447-4456

[7]

POTTER DW, 1987, J BIOL CHEM, V262, P966

[8]

Smith L. I., 1941, J AM CHEM SOC, V63, P1036

← 1 →