A catalytic asymmetric synthesis of 5,5-dimethylproline

被引：19

作者：

Elaridi, J ^{[1
]}

Jackson, WR ^{[1
]}

Robinson, AJ ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 11期

关键词：

D O I：

10.1016/j.tetasy.2005.05.003

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The methyl ester derivative of commercially available N-acetyl-allylglycine readily undergoes cross-metathesis with 2-methylbut-2-ene and ruthenium-alkylidene catalyst to afford the prenylglycine derivative. Acid-catalysed cyclisation then affords 5,5-dimethylproline in near quantitative yield and enantioselectivity. (c) 2005 Published by Elsevier Ltd.

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页码：2025 / 2029

页数：5

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