Recent developments in ring opening polymerization of lactones for biomedical applications

被引：1492

作者：

Albertsson, AC ^{[1
]}

Varma, IK

机构：

[1] Royal Inst Technol, Dept Fibre & Polymer Technol, S-10044 Stockholm, Sweden

[2] Indian Inst Technol, Ctr Polymer Sci & Engn, New Delhi 110016, India

来源：

BIOMACROMOLECULES | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1021/bm034247a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Aliphatic polyesters prepared by ring-opening polymerization of lactones are now used worldwide as bioresorbabale devices in surgery (orthopaedic devices, sutures, stents, tissue engineering, and adhesion barriers) and in pharmacology (control drug delivery). This review presents the various methods of the synthesis of polyesters and tailoring the properties by proper control of molecular weight, composition, and architecture so as to meet the stringent requirements of devices in the medical field. The effect of structure on properties and degradation has been discussed. The applications of these polymers in the biomedical field are described in detail.

引用

页码：1466 / 1486

页数：21

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