Hyperglycemia-induced mitochondrial alterations in liver

被引：54

作者：

Dey, Aparajita ^{[1
]}

Swaminathan, Kavitha ^{[1
]}

机构：

[1] Anna Univ, Div Life Sci, AU KBC Res Ctr, Madras 600044, Tamil Nadu, India

来源：

LIFE SCIENCES | 2010年 / 87卷 / 7-8期

关键词：

Hyperglycemia; Diabetes; Liver; Mitochondria; HYDROXYBUTYRATE DEHYDROGENASE-ACTIVITY; RECEPTOR-GAMMA COACTIVATOR-1-ALPHA; NONALCOHOLIC STEATOHEPATITIS NASH; STIMULATED INSULIN-SECRETION; STREPTOZOTOCIN-DIABETIC RAT; ANION TRANSPORT PROTEINS; BETA-CELL DYSFUNCTION; SKELETAL-MUSCLE; OXIDATIVE STRESS; UNCOUPLING PROTEIN-2;

D O I：

10.1016/j.lfs.2010.06.007

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The increasing prevalence of diabetes continues to be a major health issue world wide. Liver injury is highly relevant in diabetic subjects and Type 2 diabetes mellitus is an acknowledged risk factor for non-alcoholic fatty liver disease (NAFLD). Chronic hyperglycemia is an important feature of diabetes and hyperglycemia induced mitochondrial dysfunction in liver holds importance in context to NAFLD. Some of the hyperglycemia induced changes in mitochondria include decreased oxidative phosphorylation, increased oxidative stress and ultra structural abnormalities. The following review identifies the mechanisms through which hyperglycemia causes mitochondrial dysfunction in liver. (c) 2010 Elsevier Inc. All rights reserved.

引用

页码：197 / 214

页数：18

共 126 条

[1]

Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients [J].

Befroy, Douglas E. ;

Petersen, Kitt Falk ;

Dufour, Sylvie ;

Mason, Graeme F. ;

de Graaf, Robin A. ;

Rothman, Douglas L. ;

Shulman, Gerald I. .

DIABETES, 2007, 56 (05) :1376-1381

[2]

STUDIES ON THE CONTROL OF LIPOGENESIS - STRAIN DIFFERENCES IN HEPATIC-METABOLISM [J].

BERDANIER, CD ;

TOBIN, RB ;

DEVORE, V .

JOURNAL OF NUTRITION, 1979, 109 (02) :247-260

[3]

Bohan A, 2000, HEPATOLOGY, V32, p387A

[4]

ALTERATIONS IN MITOCHONDRIAL ACONITASE ACTIVITY AND RESPIRATION, AND IN CONCENTRATION OF CITRATE IN SOME ORGANS OF MICE WITH EXPERIMENTAL OR GENETIC DIABETES [J].

BOQUIST, L ;

ERICSSON, I ;

LORENTZON, R ;

NELSON, L .

FEBS LETTERS, 1985, 183 (01) :173-176

[5]

HEPATIC MITOCHONDRIAL INNER MEMBRANE-PROPERTIES AND CARNITINE PALMITOYLTRANSFERASE A AND B - EFFECT OF DIABETES AND STARVATION [J].

BRADY, LJ ;

SILVERSTEIN, LJ ;

HOPPEL, CL ;

BRADY, PS .

BIOCHEMICAL JOURNAL, 1985, 232 (02) :445-450

[6]

Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets [J].

Brown, JEP ;

Thomas, S ;

Digby, JE ;

Dunmore, SJ .

FEBS LETTERS, 2002, 513 (2-3) :189-192

[7]

A radical explanation for glucose-induced β cell dysfunction [J].

Brownlee, M .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (12) :1788-1790

[8]

Biochemistry and molecular cell biology of diabetic complications [J].

Brownlee, M .

NATURE, 2001, 414 (6865) :813-820

[9]

Fatty acid metabolism is enhanced in type 2 diabetic hearts [J].

Carley, AN ;

Severson, DL .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2005, 1734 (02) :112-126

[10]

Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells [J].

Cederbaum, Arthur I. .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2006, 21 :S22-S25

← 1 2 3 4 5 6 7 8 9 10 →