Osteopontin: a bridge between bone and the immune system

被引：145

作者：

Gravallese, EM ^{[1
]}

机构：

[1] Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 02期

关键词：

D O I：

10.1172/JCI200310109

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR (see the related article beginning on page 181) is capable of preventing inflammatory cell infiltration in arthritic joints.

引用

页码：147 / 149

页数：3

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