Osteopontin: a bridge between bone and the immune system

被引：146

作者：

Gravallese, EM ^{[1
]}

机构：

[1] Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 02期

关键词：

D O I：

10.1172/JCI200310109

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR (see the related article beginning on page 181) is capable of preventing inflammatory cell infiltration in arthritic joints.

引用

页码：147 / 149

页数：3

共 16 条

[1]

Blom T, 2003, SCIENCE, V299

[2] Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression [J].

Chellaiah, MA ;

Kizer, N ;

Biswas, R ;

Alvarez, U ;

Strauss-Schoenberger, J ;

Rifas, L ;

Rittling, SR ;

Denhardt, DT ;

Hruska, KA .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (01) :173-189

[3]

Denhardt DT, 1998, J CELL BIOCHEM, P92, DOI 10.1002/(SICI)1097-4644(1998)72:30/31+<92::AID-JCB13>3.0.CO

[4]

2-A

[5] Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin [J].

Ihara, H ;

Denhardt, DT ;

Furuya, K ;

Yamashita, T ;

Muguruma, Y ;

Tsuji, K ;

Hruska, KA ;

Higashio, K ;

Enomoto, S ;

Nifuji, A ;

Rittling, SR ;

Noda, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (16) :13065-13071

[6] Cutting edge: Attenuated experimental autoimmune encephalomyelitis in Eta-1/osteopontin-deficient mice [J].

Jansson, M ;

Panoutsakopoulou, V ;

Baker, J ;

Klein, L ;

Cantor, H .

JOURNAL OF IMMUNOLOGY, 2002, 168 (05) :2096-2099

[7] OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis [J].

Kong, YY ;

Yoshida, H ;

Sarosi, I ;

Tan, HL ;

Timms, E ;

Capparelli, C ;

Morony, S ;

Oliveira-dos-Santos, AJ ;

Van, G ;

Itie, A ;

Khoo, W ;

Wakeham, A ;

Dunstan, CR ;

Lacey, DL ;

Mak, TW ;

Boyle, WJ ;

Penninger, JM .

NATURE, 1999, 397 (6717) :315-323

[8]

MURRY CE, 1994, AM J PATHOL, V145, P1450

[9] Expression of osteopontin at sites of bone erosion in a murine experimental arthritis model of collagen-induced arthritis - Possible involvement of osteopontin in bone destruction in arthritis [J].

Ohshima, S ;

Kobayashi, H ;

Yamaguchi, N ;

Nishioka, K ;

Umeshita-Sasai, M ;

Mima, T ;

Nomura, S ;

Kon, S ;

Inobe, M ;

Uede, T ;

Saeki, Y .

ARTHRITIS AND RHEUMATISM, 2002, 46 (04) :1094-1101

[10]

Petrow PK, 2000, ARTHRITIS RHEUM, V43, P1597, DOI 10.1002/1529-0131(200007)43:7<1597::AID-ANR25>3.3.CO

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