Aminosalicylates and aspirin for colonic cancer: From anti-inflammatory to antineoplastic drugs?

被引：5

作者：

Allgayer, H

Tillmann, T

Hombach, A

Kruis, W

Pohl, C

机构：

[1] Heidelberg Univ, Akad Lehrkrankenhaus, LVA Wurttemberg, Abt Krebsnachsorge Rehaklin Ob Tauber, D-97980 Bad Mergentheim, Germany

[2] Univ Cologne, Akad Lehrkrankenhaus, Evangel Krankenhaus Koln Kalk, Innere Abt, D-5000 Cologne 41, Germany

来源：

ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2000年 / 38卷 / 12期

关键词：

5-ASA; aspirin; antitumor effects; inhibition of prostaglandins/leukotriene synthesis COX-2 inhibition; oxidative DNA damage; apoptosis;

D O I：

10.1055/s-2000-10027

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of this article is to review potential antineoplastic properties of antiinflammatory compounds commonly used in various inflammatory diseases such as aminosalicylates, aspirin and other nonsteroidal drugs. Starting from experimental and epidemiologic evidence showing prophylaxis and/or tumor regression/suppression, specific antineoplastic actions especially the inhibition of cyclooxygenase-(COX)dependent and COX-independent steps including the role of transscription factor (NFkB) in the cell cycle regulation are reviewed. In addition other mechanisms by which these drugs may exert antitumor effects, also may be important such as induction of apoptosis of cancer cells and/or inhibition of potentially carcinogenic oxidative DNA damage. Based on this knowledge potential clinical implications are discussed.

引用

页码：963 / 970

页数：8

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