The biochemistry of memory: The 26 year journey of a 'new and specific hypothesis'

被引：44

作者：

Baudry, Michel ^{[1
]}

Bi, Xiaoning ^{[2
]}

Gall, Christine

Lynch, Gary ^{[3
,4
]}

机构：

[1] Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA

[2] Western Univ Hlth Sci, COMP, Dept Basic Med Sci, Pomona, CA 91766 USA

[3] Univ Calif Irvine, Dept Anat & Neurobiol, Gillespie Neurosci Res Facil, Irvine, CA 92697 USA

[4] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 95卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Learning and memory; Hippocampus; Calpain; Actin cytoskeleton; BDNF; LONG-TERM POTENTIATION; FRAGILE-X-SYNDROME; GLUTAMATE-RECEPTOR-BINDING; RESCUES SYNAPTIC PLASTICITY; CALCIUM-ACTIVATED PROTEASE; EPIDERMAL-GROWTH-FACTOR; NEUROTROPHIC FACTOR; HUNTINGTONS-DISEASE; AMPA RECEPTORS; MOUSE MODEL;

D O I：

10.1016/j.nlm.2010.11.015

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

This Special Issue of Neurobiology of Learning and Memory dedicated to Dr. Richard Thompson to celebrate his 80th birthday and his numerous contributions to the field of learning and memory gave us the opportunity to revisit the hypothesis we proposed more than 25 years ago regarding the biochemistry of learning and memory. This review summarizes our early 1980s hypothesis and then describes how it was tested and modified over the years following its introduction. We then discuss the current status of the hypothesis and provide some examples of how it has led to unexpected insights into the memory problems that accompany a broad range of neuropsychiatric disorders. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：125 / 133

页数：9

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