Autoimmunity to glutamate receptors in Rasmussen's encephalitis: A rare finding or the tip of an iceberg?

Neurological disorders demonstrate remarkable specificity in afflicting precise brain regions. They are most frequently sporadic in origin and they are devastating because of the progressive impairment of cognitive and/or motor functions. Our studies have found that some neurological diseases may actually reflect a dysfunction of the immune system in which highly specific autoantibodies are generated that bind neuronal glutamate receptors and directly affect their function in normal neurotransmission. Understanding at the molecular level how the immune system participates in neurological disease will ultimately lead to more effective therapeutic approaches to some of these disorders with presently unknown etiology.