In vitro activities of three nonfluorinated quinolones against representative bacterial isolates

被引：20

作者：

Barry, AL ^{[1
]}

Fuchs, PC ^{[1
]}

Brown, SD ^{[1
]}

机构：

[1] Inst Clin Microbiol, Wilsonville, OR 97070 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期

关键词：

D O I：

10.1128/AAC.45.6.1923-1927.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

In vitro susceptibility tests were performed to document the inhibitory activities of three nonfluorinated quinolone (NFQ) compounds (PGE 9262932, PGE 9509924, and PGE 4175997) compared to those of ciprofloxacin, levofloxacin, and trovafloxacin against 3,030 bacterial isolates. The spectra of the NFQ agents included most gram-positive species as well as quinolone-susceptible Enterobacteriaceae. Ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus strains were inhibited by the NFQ series at less than or equal to1.0 mug/ml. The NFQ compounds were not very active against Pseudomonas aeruginosa and most other nonfermentative gramnegative bacilli. Against other species, the potency of the NFQ agents was similar to that of trovafloxacin. Continued investigation of the NFQ compounds seems to be warranted.

引用

页码：1923 / 1927

页数：5

共 5 条

[1]

Barry A.L, 1990, NEW GENERATION QUINO, P79

[2]

New uses for new and old quinolones and the challenge of resistance [J].