Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells

被引：39

作者：

Fan, SR ^{[1
]}

Ho, IC ^{[1
]}

Yeoh, FLF ^{[1
]}

Lin, CJ ^{[1
]}

Lee, TC ^{[1
]}

机构：

[1] ACAD SINICA,INST BIOMED SCI,TAIPEI 11529,TAIWAN

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY | 1996年 / 368卷 / 3-4期

关键词：

sodium arsenite; squalene; sister chromatid exchange; micronucleus;

D O I：

10.1016/S0165-1218(96)90058-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Arsenic, widely distributed throughout our environment, is a well-established human carcinogen. We report here that squalene, a natural fish oil, is a potential agent in the reduction of sodium arsenite-induced sister chromatid exchange (SCE) and micronuclei in Chinese hamster ovary (CHO-KI) cells. Squalene dose-dependently inhibited sodium arsenite-induced SCE. At the highest concentration (160 mu M), squalene reduced the SCE frequency from 8.85 to 6.47 SCEs per cell which is very close to the background level (5.82 SCEs per cell). Sodium arsenite dose-dependently induces micronuclei in CHO-Kl cells, and squalene at 80 mu M significantly inhibits arsenite-induced micronuclei. However, squalene did not eliminate the killing effects of arsenite on the cells and only slightly decreased intracellular accumulation of arsenic.

引用

页码：165 / 169

页数：5

共 30 条

[1] EVIDENCE FOR OXIDATIVE DAMAGE TO RED-BLOOD-CELLS IN MICE INDUCED BY ARSINE GAS [J].