Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae

被引：69

作者：

Preston, Julie A.

Essilfie, Ama-Tawiah

Horvat, Jay C.

Wade, Margaret A.

Beagley, Kenneth W.

Gibson, Peter G.

Foster, Paul S.

Hansbro, Philip M. ^{[1
]}

机构：

[1] Univ Newcastle, Fac Hlth, Sch Biomed Sci, Ctr Asthma & Respiratory Dis, Newcastle, NSW 2308, Australia

[2] Hunter Med Res Inst, Vaccines Immun Viruses & Asthma Grp, Newcastle, NSW, Australia

[3] John Hunter Hosp, Resp & Sleep Med, Newcastle, NSW, Australia

[4] Univ Newcastle, Sch Med Pract, Resp & Sleep Med, Newcastle, NSW 2308, Australia

[5] Australian Natl Univ, John Curtin Sch Med Res, Div Mol BioSci, Canberra, ACT 2601, Australia

来源：

VACCINE | 2007年 / 25卷 / 48期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

asthma; Streptococcus pneumoniae; immunomodulation;

D O I：

10.1016/j.vaccine.2007.09.034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a common inflammatory disease of the airways. Current therapies alleviate symptoms but do not treat the disease. We aim to develop effective immunomodulatory therapies (IMTs) for asthma that target the underlying causes of disease based on Streptococcus pneumoniae (Spn). The effect of Spn IMT on the development of asthma [allergic airways disease (AAD)] was determined in mice. Killed Spn was administered before, during or after ovalbumin sensitization, and the subsequent development of AAD was assessed. IMT attenuated T cell cytokine production, goblet cell hyperplasia, airways hyperresponsiveness (AHR), and eosinophil numbers in the blood, bronchoalveolar lavage fluid and peribronchial tissue. This indicates the potential of Spn as an IMT for asthma. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8154 / 8162

页数：9

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