Parental concordance and offspring risk for anxiety, conduct, depressive, and substance use disorders

被引:13
作者
Johnson, Jeffrey G.
Cohen, Patricia
Kasen, Stephanie
Brook, Judith S.
机构
[1] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[2] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA
[3] NYU, Dept Psychiat, New York, NY 10016 USA
关键词
anxiety; depression; conduct disorder; substance use disorder;
D O I
10.1159/000112028
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Although parental concordance for any psychiatric disorder is known to be associated with elevated risk for offspring disorder, little evidence is currently available from prospective longitudinal studies regarding the association of parental concordance with offspring risk for anxiety, conduct, depressive, and substance use disorders. Sampling and Methods: Psychiatric interviews were conducted with 593 mothers and their biological offspring at mean offspring ages 14, 16, 22, and 33. Results: Offspring risk for >= 1 psychiatric disorder was significantly greater if both parents had a lifetime history of psychiatric disorder than if only one parent had a lifetime history of disorder. Parental concordance for generalized anxiety disorder (GAD) was associated with a significant increase in offspring risk for anxiety disorders, above and beyond the risk attributable to having one affected parent. In addition, parental concordance for GAD was associated with elevated risk for offspring depressive disorders, and parental concordance for substance use disorders was associated with elevated offspring risk for conduct disorder. Conclusions: Parental concordance for GAD may be associated with elevated risk for offspring anxiety disorder, above and beyond the risk associated with having one affected parent.
引用
收藏
页码:124 / 128
页数:5
相关论文
共 21 条
[1]   COMPARISON OF DISK AND K-SADS-P INTERVIEWS OF AN EPIDEMIOLOGIC SAMPLE OF CHILDREN [J].
COHEN, P ;
OCONNOR, P ;
LEWIS, S ;
VELEZ, CN ;
MALACHOWSKI, B .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1987, 26 (05) :662-667
[2]  
Cohen P., 1996, LIFE VALUES ADOLESCE
[3]  
Costello EJ, 1984, TESTING NIMH DIAGNOS
[4]   HOPKINS SYMPTOM CHECKLIST (HSCL) - SELF-REPORT SYMPTOM INVENTORY [J].
DEROGATIS, LR ;
LIPMAN, RS ;
RICKELS, K ;
UHLENHUTH, EH ;
COVI, L .
BEHAVIORAL SCIENCE, 1974, 19 (01) :1-15
[5]   Influence of parental concordance for psychiatric disorders on psychopathology in offspring [J].
Dierker, LC ;
Merikangas, KR ;
Szatmari, P .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1999, 38 (03) :280-288
[6]  
First MB, 2000, STRUCTURED CLIN INTE
[7]  
Foley DL, 2001, J CHILD PSYCHOL PSYC, V42, P381
[8]  
HESSELBROCK V, 1982, ARCH GEN PSYCHIAT, V39, P674
[9]  
HOSTETTER AM, 1983, AM J PSYCHIAT, V140, P62
[10]   Association of maladaptive parental behavior with psychiatric disorder among parents and their offspring [J].
Johnson, JG ;
Cohen, P ;
Kasen, S ;
Smailes, E ;
Brook, JS .
ARCHIVES OF GENERAL PSYCHIATRY, 2001, 58 (05) :453-460