Pitch-Dependent Acceleration of Neurite Outgrowth on Nanostructured Anodized Aluminum Oxide Substrates

被引:46
作者
Cho, Woo Kyung [2 ]
Kang, Kyungtae [2 ]
Kang, Gyumin [1 ]
Jang, Min Jee [1 ]
Nam, Yoonkey [1 ]
Choi, Insung S. [1 ,2 ]
机构
[1] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Taejon 305701, South Korea
[2] Korea Adv Inst Sci & Technol, Dept Chem, Mol Level Interface Res Ctr, Taejon 305701, South Korea
关键词
anodized aluminum oxide; cell adhesion; nanostructures; neurite outgrowth; neurochemistry; HIPPOCAMPAL-NEURONS; CONTACT GUIDANCE; IN-VITRO; SILICON; GROWTH; CELLS; FILMS; FABRICATION; NANOWIRES; ADHESION;
D O I
10.1002/anie.201003307
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Pitching in to help: When nanostructured anodized aluminum oxide substrates of four different types were used as nanotopographical environments for in vitro neuronal culture, the average neurite outgrowth was much faster on surfaces with a 400 nm pitch than on surfaces with a 60 nm pitch (see AFM images of two substrates and fluorescence micrographs of hippocampal neurons after culture for 2 days on these substrates). Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:10114 / 10118
页数:5
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