Signatures of Adaptation to Obligate Biotrophy in the Hyaloperonospora arabidopsidis Genome

被引：348

作者：

Baxter, Laura ^{[2
]}

Tripathy, Sucheta ^{[3
]}

Ishaque, Naveed ^{[4
]}

Boot, Nico ^{[5
]}

Cabral, Adriana ^{[5
]}

Kemen, Eric ^{[4
]}

Thines, Marco ^{[4
,6
,7
]}

Ah-Fong, Audrey ^{[8
]}

Anderson, Ryan ^{[1
]}

Badejoko, Wole ^{[2
]}

Bittner-Eddy, Peter ^{[2
]}

Boore, Jeffrey L. ^{[9
]}

Chibucos, Marcus C. ^{[3
]}

Coates, Mary ^{[2
]}

Dehal, Paramvir ^{[10
]}

Delehaunty, Kim ^{[11
]}

Dong, Suomeng ^{[12
,13
]}

Downton, Polly ^{[2
]}

Dumas, Bernard ^{[14
,15
]}

Fabro, Georgina ^{[4
]}

Fronick, Catrina ^{[11
]}

Fuerstenberg, Susan I. ^{[9
]}

Fulton, Lucinda ^{[11
]}

Gaulin, Elodie ^{[14
,15
]}

Govers, Francine ^{[16
,17
]}

Hughes, Linda ^{[2
]}

Humphray, Sean ^{[18
]}

Jiang, Rays H. Y. ^{[16
,17
,19
]}

Judelson, Howard ^{[8
]}

Kamoun, Sophien ^{[4
]}

Kyung, Kim ^{[11
]}

Meijer, Harold ^{[16
,17
]}

Minx, Patrick ^{[11
]}

Morris, Paul ^{[20
]}

Nelson, Joanne ^{[11
]}

Phuntumart, Vipa ^{[20
]}

Qutob, Dinah ^{[12
]}

Rehmany, Anne ^{[2
]}

Rougon-Cardoso, Alejandra ^{[4
]}

Ryden, Peter ^{[2
]}

Torto-Alalibo, Trudy ^{[3
]}

Studholme, David ^{[4
]}

Wang, Yuanchao ^{[13
]}

Win, Joe ^{[4
]}

Wood, Jo ^{[18
]}

Clifton, Sandra W. ^{[11
]}

Rogers, Jane ^{[18
]}

Van den Ackerveken, Guido ^{[5
]}

Jones, Jonathan D. G. ^{[4
]}

McDowell, John M. ^{[1
]}

机构：

[1] Virginia Polytech Inst & State Univ, Dept Plant Pathol Physiol & Weed Sci, Blacksburg, VA 24061 USA

[2] Univ Warwick, Sch Life Sci, Wellesbourne CV35 9EF, Warwick, England

[3] Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA

[4] John Innes Ctr, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England

[5] Univ Utrecht, Dept Biol, NL-3584 CH Utrecht, Netherlands

[6] Biodivers & Climate Res Ctr BiK F, D-60325 Frankfurt, Germany

[7] Goethe Univ Frankfurt, Dept Biol Sci, Inst Ecol Evolut & Divers, D-60323 Frankfurt, Germany

[8] Univ Calif Riverside, Dept Plant Pathol & Microbiol, Riverside, CA 92521 USA

[9] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[10] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

[11] Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63110 USA

[12] Agr & Agri Food Canada, London, ON N5V 4T3, Canada

[13] Nanjing Agr Univ, Dept Plant Pathol, Nanjing 210095, Peoples R China

[14] Univ Toulouse, UPS, F-31326 Castanet Tolosan, France

[15] CNRS, F-31326 Castanet Tolosan, France

[16] Wageningen Univ, Phytopathol Lab, NL-16708 PB Wageningen, Netherlands

[17] Ctr BioSyst Genom, NL-16708 PB Wageningen, Netherlands

[18] Sanger, Cambridge CB10 1SA, England

[19] MIT & Harvard, Broad Inst, Cambridge, MA 02141 USA

[20] Bowling Green State Univ, Dept Biol Sci, Bowling Green, OH 43403 USA

来源：

SCIENCE | 2010年 / 330卷 / 6010期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 美国国家科学基金会; 美国食品与农业研究所;

关键词：

SOJAE-EFFECTOR AVR1B; DOWNY MILDEW; PHYTOPHTHORA; PLANT; THALIANA; CELLS; SUPPRESSION; PARASITES; PROTEINS; DELIVERY;

D O I：

10.1126/science.1195203

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.

引用

页码：1549 / 1551

页数：3

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