Quantitative ultrasound using backscatter analysis in Duchenne and Becker muscular dystrophy

被引：61

作者：

Zaidman, Craig M. ^{[1
,2
]}

Connolly, Anne M. ^{[1
,2
]}

Malkus, Elizabeth C. ^{[1
]}

Florence, Julaine M. ^{[1
]}

Pestronk, Alan ^{[1
,3
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[3] Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

NEUROMUSCULAR DISORDERS | 2010年 / 20卷 / 12期

关键词：

Ultrasound; Backscatter; Myopathy; Muscle; Children; Duchenne muscular dystrophy; SKELETAL-MUSCLE; DISEASE; PROGRESSION; BOYS;

D O I：

10.1016/j.nmd.2010.06.019

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Evaluation of ultrasound images of muscle with calibrated muscle backscatter (cMB) provides reproducible quantitative measurements of muscle pathology Increased cMB is associated with greater muscle pathology We used cMB to evaluate the severity of muscle pathology in 55 patients with Duchenne and Becker Muscular Dystrophy (D/BMD) compared to 77 controls cMB was also compared to measurements of strength and function cMB in DMD and BMD increased linearly with age and was higher than in controls when groups are compared cMB increased twice as fast with age in DMD than in BMD In DMD cMB was higher with reduced function and strength Ultrasound measurement of muscle pathology using cMB is a sensitive and objective quantitative technique for determining the severity of muscle pathology in dystrophinopathies Longitudinal studies are required to determine the sensitivity of this measure to changes in pathology over time (C) 2010 Elsevier B V All rights reserved

引用

页码：805 / 809

页数：5

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