Use of viral vectors for vaccine production in plants

被引:124
作者
Cañizares, MC [1 ]
Nicholson, L [1 ]
Lomonossoff, GP [1 ]
机构
[1] John Innes Ctr Plant Sci Res, Norwich NR4 7UH, Norfolk, England
关键词
epitope presentation; plant virus; polypeptide expression; viral vector;
D O I
10.1111/j.1440-1711.2005.01339.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The small size of plant viral genomes, the ease with which they can be manipulated, and the simplicity of the infection process is making the viral vectors an attractive alternative to the transgenic systems for the expression of foreign proteins in plants. One use of these virus expression systems is for vaccine production. There are two basic types of viral system that have been developed for the production of immunogenic peptides and proteins in plants: epitope presentation and polypeptide expression systems. In this review, we discuss advances made in this field.
引用
收藏
页码:263 / 270
页数:8
相关论文
共 73 条
  • [1] MULTICOMPONENT RNA PLANT-VIRUS INFECTION DERIVED FROM CLONED VIRAL CDNA
    AHLQUIST, P
    FRENCH, R
    JANDA, M
    LOESCHFRIES, LS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (22): : 7066 - 7070
  • [2] Engineering zucchini yellow mosaic potyvirus as a non-pathogenic vector for expression of heterologous proteins in cucurbits
    Arazi, T
    Slutsky, SG
    Shiboleth, YM
    Wang, YZ
    Rubinstein, M
    Barak, S
    Yang, J
    Gal-On, A
    [J]. JOURNAL OF BIOTECHNOLOGY, 2001, 87 (01) : 67 - 82
  • [3] Display of epitopes on the surface of tobacco mosaic virus: Impact of charge and isoelectric point of the epitope on virus-host interactions
    Bendahmane, M
    Koo, M
    Karrer, E
    Beachy, RN
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1999, 290 (01) : 9 - 20
  • [4] Pseudomonas aeruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed an a plant virus
    Brennan, FR
    Jones, TD
    Gilleland, LB
    Bellaby, T
    Xu, F
    North, PC
    Thompson, A
    Staczek, J
    Lin, T
    Johnson, JE
    Hamilton, WDO
    Gilleland, HE
    [J]. MICROBIOLOGY-SGM, 1999, 145 : 211 - 220
  • [5] A chimaeric plant virus vaccine protects mice against a bacterial infection
    Brennan, FR
    Gilleland, LB
    Staczek, J
    Bendig, MM
    Hamilton, WDO
    Gilleland, HE
    [J]. MICROBIOLOGY-SGM, 1999, 145 : 2061 - 2067
  • [6] CHAPMAN S, 1992, PLANT J, V2, P549
  • [7] Cowpea mosaic virus: From the presentation of antigenic peptides to the display of active biomaterials
    Chatterji, A
    Burns, LL
    Taylor, SS
    Lomonossoff, GP
    Johnson, JE
    Lin, T
    Porta, C
    [J]. INTERVIROLOGY, 2002, 45 (4-6) : 362 - 370
  • [8] A plant virus vector for systemic expression of foreign genes in cereals
    Choi, IR
    Stenger, DC
    Morris, TJ
    French, R
    [J]. PLANT JOURNAL, 2000, 23 (04) : 547 - 555
  • [9] Assembly and movement of a plant virus carrying a green fluorescent protein overcoat
    Cruz, SS
    Chapman, S
    Roberts, AG
    Roberts, IM
    Prior, DAM
    Oparka, KJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) : 6286 - 6290
  • [10] Plant-derived vaccine protects target animals against a viral disease
    Dalsgaard, K
    Uttenthal, A
    Jones, TD
    Xu, F
    Merryweather, A
    Hamilton, WDO
    Langeveld, JPM
    Boshuizen, RS
    Kamstrup, S
    Lomonossoff, GP
    Porta, C
    Vela, C
    Casal, JI
    Meloen, RH
    Rodgers, PB
    [J]. NATURE BIOTECHNOLOGY, 1997, 15 (03) : 248 - 252