Age-related changes in peroxisomal membrane protein 70 and superoxide dismutase 1 in transgenic G93A mice

被引：4

作者：

Ilieva, HS ^{[1
]}

Nagano, I ^{[1
]}

Murakami, T ^{[1
]}

Shiote, M ^{[1
]}

Manabe, Y ^{[1
]}

Abe, K ^{[1
]}

机构：

[1] Okayama Univ, Dept Neurol, Grad Sch Med & Dent, Okayama 7008558, Japan

来源：

NEUROLOGICAL RESEARCH | 2003年 / 25卷 / 04期

关键词：

amyotrophic lateral sclerosis; Cu/Zn superoxide dismutase; peroxisome;

D O I：

10.1179/016164103101201607

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Peroxisomal membrane protein 70 (PMP70) and Cu/Zn superoxide dismutase (SOD1) were examined in the spinal cords of transgenic (Tg) mice expressing a human mutant SOD1 protein (G93A) and their age-matched controls at 8, 20 and 32 weeks by immunohistochemistry. At pre-symptomatic 20 weeks and symptomatic 32 weeks, PMP70 was reduced in the cytoplasm of motor neurons in Tg animals and increased in glial cells in anterior horn at late age. SOD1 showed a progressive increase of dot-like deposits in the neuropil of anterior horn of Tg mice, and a late decrease of signal intensity in the white matter and motor neurons at 32 weeks. It is conceivable that reduction of PMP70 might underlie decrease in peroxisomal functions and increase in oxidative stress that is well documented in this animal model.

引用

页码：423 / 426

页数：4

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