Micro-Masonry: Construction of 3D Structures by Microscale Self-Assembly

被引:87
作者
Fernandez, Javier G. [1 ,2 ,3 ]
Khademhosseini, Ali [1 ,2 ,3 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Biomed Engn,Dept Med, Boston, MA 02115 USA
[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[3] Harvard Univ, Wyss Inst Biologically Inspired Engn, Boston, MA 02115 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
CELL-LADEN MICROGELS; IN-VITRO; FABRICATION; HYDROGELS; MICROSTRUCTURES; OBJECTS; ARRAYS; LIGHT;
D O I
10.1002/adma.200903893
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A biocompatible method for general construction of 3D structures by aggregation of micrometric polymeric subunits is presented. Shape-controlled microgels are forced to self-assemble, in a structure similar to a brick wall, in different shapes by limiting their movement onto a surface. Scaffolds with high spatial resolution in the aggregation and composed by the addition of multiple layers are produced.
引用
收藏
页码:2538 / 2541
页数:4
相关论文
共 21 条
[1]   Self-assembly of mesoscale objects into ordered two-dimensional arrays [J].
Bowden, N ;
Terfort, A ;
Carbeck, J ;
Whitesides, GM .
SCIENCE, 1997, 276 (5310) :233-235
[2]   Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro [J].
Bryant, SJ ;
Nuttelman, CR ;
Anseth, KS .
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2000, 11 (05) :439-457
[3]   Direct patterning of composite biocompatible microstructures using microfluidics [J].
Cheung, Yuk Kee ;
Gillette, Brian M. ;
Zhong, Ming ;
Ramcharan, Sharmilee ;
Sia, Samuel K. .
LAB ON A CHIP, 2007, 7 (05) :574-579
[4]   Self-assembly of 10-μm-sized objects into ordered three-dimensional arrays [J].
Clark, TD ;
Tien, J ;
Duffy, DC ;
Paul, KE ;
Whitesides, GM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (31) :7677-7682
[5]   Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs [J].
Du, Yanan ;
Lo, Edward ;
Ali, Shamsher ;
Khademhosseini, Ali .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (28) :9522-9527
[6]   Method of Bottom-Up Directed Assembly of Cell-Laden Microgels [J].
Du, Yanan ;
Lo, Edward ;
Vidula, Mahesh K. ;
Khabiry, Masoud ;
Khademhosseini, Ali .
CELLULAR AND MOLECULAR BIOENGINEERING, 2008, 1 (2-3) :157-162
[7]   Complex Microstructured 3D Surfaces Using Chitosan Biopolymer [J].
Fernandez, Javier G. ;
Mills, Christopher A. ;
Samitier, Josep .
SMALL, 2009, 5 (05) :614-620
[8]   DIRECT MEASUREMENT OF THE EFFECT OF MENISCUS FORCES ON ADHESION - STUDY OF THE APPLICABILITY OF MACROSCOPIC THERMODYNAMICS TO MICROSCOPIC LIQUID INTERFACES [J].
FISHER, LR ;
ISRAELACHVILI, JN .
COLLOIDS AND SURFACES, 1981, 3 (04) :303-319
[9]   Multilayer micromolding of degradable polymer tissue engineering scaffolds [J].
Gallego, Daniel ;
Ferrell, Nicholas ;
Sun, Yang ;
Hansford, Derek J. .
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2008, 28 (03) :353-358
[10]   Forming electrical networks in three dimensions by self-assembly [J].
Gracias, DH ;
Tien, J ;
Breen, TL ;
Hsu, C ;
Whitesides, GM .
SCIENCE, 2000, 289 (5482) :1170-1172