Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin A release

被引：80

作者：

Coyle, EA

Cha, R

Rybak, MJ

机构：

[1] Wayne State Univ, Eugene Applebaum Coll Pharm & Hlth Sci, Antiinfect Res Lab, Dept Pharm Practice, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Detroit, MI 48201 USA

[3] Univ Houston, Coll Pharm, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 05期

关键词：

D O I：

10.1128/AAC.47.5.1752-1755.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An in vitro model was used to compare the effects of linezolid, clindamycin, and penicillin, alone and in combination, on streptococcal pyrogenic exotoxin A (SPE A) release against virulent group A streptococci (GAS). All regimens exhibited lower (P<0.05) SPE A release at 1 h than those with penicillin alone. Linezolid and clindamycin, alone or in combination with penicillin, may optimize the treatment of GAS infections by reducing bacterial burden and exotoxin release.

引用

页码：1752 / 1755

页数：4

共 24 条

[1] INVITRO MODEL FOR SIMULTANEOUS SIMULATION OF THE SERUM KINETICS OF 2 DRUGS WITH DIFFERENT HALF-LIVES [J].

BLASER, J .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1985, 15 :125-130

[2] Bactericidal activities of cefprozil, penicillin, cefaclor, cefixime, and loracarbef against penicillin-susceptible and -resistant Streptococcus pneumoniae in an in vitro pharmacodynamic infection model [J].

Cappelletty, DM ;

Rybak, MJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (05) :1148-1152

[3]

Dresser LD, 1998, PHARMACOTHERAPY, V18, P456

[4] POTENTIATION OF OPSONIZATION AND PHAGOCYTOSIS OF STREPTOCOCCUS-PYOGENES FOLLOWING GROWTH IN THE PRESENCE OF CLINDAMYCIN [J].

GEMMELL, CG ;

PETERSON, PK ;

SCHMELING, D ;

KIM, Y ;

MATHEWS, J ;

WANNAMAKER, L ;

QUIE, PG .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (05) :1249-1256

[5]

GEMMELL CG, 1992, DIAGN MICR INFEC DIS, V15, pS67

[6] Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid [J].

Gemmell, CG ;

Ford, CW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 50 (05) :665-672

[7] MOLECULAR ANALYSIS OF PYROGENIC EXOTOXINS FROM STREPTOCOCCUS-PYOGENES ISOLATES ASSOCIATED WITH TOXIC SHOCK-LIKE SYNDROME [J].

HAUSER, AR ;

STEVENS, DL ;

KAPLAN, EL ;

SCHLIEVERT, PM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (08) :1562-1567

[8] A two-component regulatory system, CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors, hyaluronic acid capsule, streptolysin S, and pyrogenic exotoxin B [J].

Heath, A ;

DiRita, VJ ;

Barg, NL ;

Engleberg, NC .

INFECTION AND IMMUNITY, 1999, 67 (10) :5298-5305

[9] In-vitro bactericidal activity of quinupristin/dalfopristin alone and in combination against resistant strains of Enterococcus species and Staphylococcus aureus [J].

Kang, SL ;

Rybak, MJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 39 :33-39

[10] Analysis of tire superantigenic activity of mutant and allelic forms of streptococcal pyrogenic exotoxin A [J].

Kline, JB ;

Collins, CM .

INFECTION AND IMMUNITY, 1996, 64 (03) :861-869

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