Syntheses of 2H-labelled dihydropyrimidinediones and their metabolites

被引：3

作者：

Heinkele, G

Hofmann, U

Opitz, J

Mürdter, TE

机构：

[1] Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany

[2] Univ Stuttgart, Inst Organ Chem, D-70569 Stuttgart, Germany

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2001年 / 44卷 / 01期

关键词：

pyrimidinones; uracil; thymine; amino acids; catalytic deuteriation;

D O I：

10.1002/jlcr.426

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Starting with uracil or thymine, [5,5,6,6-H-2(4)]-dihydrouracil and [5,6,6,a,a,a,-H-2(6)]-dihydrothymine were synthesised in high yields by catalytic deuteriation. Subsequent hydrolyses resulted in the corresponding beta -ureidoalkanoic acids and beta -aminoacids.

引用

页码：7 / 11

页数：5

共 8 条

[1] Dihydropyridmidinase deficiency and congenital microvillous atrophy: Coincidence or genetic relation? [J].