Predicting synthetic accessibility: Application in drug discovery and development

被引：50

作者：

Baber, JC ^{[1
]}

Feher, M ^{[1
]}

机构：

[1] SignalGene Inc, Guelph, ON N1G 4P7, Canada

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 06期

关键词：

synthetic accessibility; synthetic feasibility; drug discovery; drug development; screening; prioritization; retrosynthetic analysis;

D O I：

10.2174/1389557043403765

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The estimation and use of synthetic accessibility in the drug discovery process is discussed. A distinction is drawn between synthetic feasibility and accessibility and the practical uses of an accessibility score are examined. Various techniques used in the estimation of accessibility are described and their utility and potential accuracy compared.

引用

页码：681 / 692

页数：12

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