Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart

被引：52

作者：

Mojzisová, A ^{[1
]}

Krizanová, O ^{[1
]}

Záciková, L ^{[1
]}

Komínková, V ^{[1
]}

Ondrias, K ^{[1
]}

机构：

[1] Slovak Acad Sci, Inst Mol Physiol & Genet, Bratislava 83334, Slovakia

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2001年 / 441卷 / 05期

关键词：

nicotinic acid adenine dinucleotide phosphate NAADP; calcium release; ryanodine calcium channel; heart;

D O I：

10.1007/s004240000465

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Nicotinic acid adenine dinucleotide phosphate (NAADP), a molecule derived from nicotinamide adenine dinucleotide phosphate (NADP(+)), is a recently identified nucleotide that activates Ca2+ release from intracellular stores in invertebrate eggs and in mammalian cells. NAADP could function as an intracellular messenger for mobilizing internal Ca2+ stores, however the targets and nature of NAADP-induced Ca2+ release are unknown. We report here that NAADP (3-10 muM) induces Ca2+ release from rat heart microsomes and that NAADP (1-10 muM) activates single ryanodine receptor/calcium release channels (RyR2) from dog heart incorporated into bilayer lipid membranes. The results indicate that NAADP may play a role in cardiac excitation-contraction coupling by acting on RyR2 channels.

引用

页码：674 / 677

页数：4

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