Effects of oxytocin on recollections of maternal care and closeness

被引:180
作者
Bartz, Jennifer A. [1 ]
Zaki, Jamil [2 ]
Ochsner, Kevin N. [3 ]
Bolger, Niall [3 ]
Kolevzon, Alexander [1 ]
Ludwig, Natasha [1 ]
Lydon, John E. [4 ]
机构
[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
[2] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA
[3] Columbia Univ, Dept Psychol, New York, NY 10027 USA
[4] McGill Univ, Dept Psychol, Montreal, PQ H3A 2T5, Canada
关键词
neurohypophyseal hormones; social cognition; social memory; individual differences; Syntocinon; PARENTAL BONDING INSTRUMENT; SOCIAL ATTACHMENT; MEMORY; ACTIVATION; ADULTHOOD; STABILITY; MODELS; SYSTEM;
D O I
10.1073/pnas.1012669107
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Although the infant-caregiver attachment bond is critical to survival, little is known about the biological mechanisms supporting attachment representations in humans. Oxytocin plays a key role in attachment bond formation and maintenance in animals and thus could be expected to affect attachment representations in humans. To investigate this possibility, we administered 24 IU intranasal oxytocin to healthy male adults in a double-blind, placebo-controlled, crossover designed study and then assessed memories of childhood maternal care and closeness-two features of the attachment bond. We found that the effects of oxytocin were moderated by the attachment representations people possess, with less anxiously attached individuals remembering their mother as more caring and close after oxytocin (vs. placebo) but more anxiously attached individuals remembering their mother as less caring and close after oxytocin (vs. placebo). These data contrast with the popular notion that oxytocin has broad positive effects on social perception and are more consistent with the animal literature, which emphasizes oxytocin's role in encoding social memories and linking those memories to the reward value of the social stimulus.
引用
收藏
页码:21371 / 21375
页数:5
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